Bio-Gen Pharmaceuticals

About Us

Bio-Gen is founded in year 2000. The aim of our company is producing by contract manufacturing, supplying and marketing pharmaceuticals to Turkish Market without abandoning its vision and principal. Our Headquarter Office is located in Ankara, capital of Turkey and branch office is located in Istanbul committing to our headquarter, being represented as a director region.

CEO Message

Welcome,

Bio-Gen Pharmaceuticals is a pharmaceutical company with a leading position in innovation and healthcare. We add value to the healthcare industry worldwide with our customer-focused approach and constantly evolving product portfolio. Our mission is to provide the highest quality medicines to protect and improve human health.

In line with this mission, we work to touch the lives of more people every day and offer innovative solutions. We strive to raise society's health standards by responding quickly and effectively to the changing needs in the health industry. As Bio-Gen İlaç, we attach great importance to scientific research and development. Using the latest technologies, we work to develop new and effective drugs for the treatment and prevention of diseases.

At the same time, we adhere to ethical values and carry out all our activities with the principle of transparency and honesty. Together with our expert team and global partners in the industry, we constantly offer solutions tailored to our customers' needs. We work for a sustainable future in the field of healthcare and contribute to the well-being of our society. Join us to join the Bio-Gen İlaç family and be one step ahead in the field of healthcare. Let's work together to build a healthier and happier world.

Stay healthy,

Necati ADAM
General manager

Contact Us

Milestones

Our Licensors

2000

Photopheresis treatment

Uvadex – Uvar XTS

Uvadex (methoxsalen) sterile solution is indicated for extracorporealadministration with the UVAR or UVAR XTS and CellExPhotopheresis Systemin the palliative treatment of the skin manifestations of Cutaneous T- Cell Lymphoma (CTCL) that is unresponsive to other forms of treatment.

PHOTOPHERESIS
The XTS System is the latest example of our ongoing commitment to the field of photoimmune therapy. By incorporating the most advanced and innovativetechnologies into our instrument, we have provided a new level of patient-focused therapy, allowing medical professionals to concentrate more on thepatient and less on the procedure.

2003

First licence Ostenil

(For the intraarticular injection)
Ostenil® Ostenil Plus and Ostenil tendon are agents that have been developed specifically for the treatment of osteoarthritis and tendondisorders. They are solutions of hyaluronan (sodium hyaluronate) and is administered intra-articularly or intra-tendon as a course of three to weekly injections. We are market leader in market of intraarticular Hyaluronic Acid injection for Osteoarthritis.

2004

Brunac (Drug)

Mucolytic and Corneal Collagenase Enzyme Inhinbitor eye drop. It is indicatedin Corneal ulcers,kerathopathies of different etiology,corneal affections due toaltered lachrymal secretion.

2007

Brumeton (Drug)

Antibiotic (Betamethasone) and corticosteroid (Sulphasetamide) combination for the treatment of Blepharitis and Blepharoconjunctivitis.

2008

Taurolite (Drug)

Active ingredient: Tauroursodeoxycholic acid
Indication: Gall stones, chronic liver diseases, primary biliary cirrhosis

2009

Artrodar (Drug)

Specific long term treatment of degenerative joint diseases
(osteoarthritisand related diseases).

2010

Acnegen (Drug)

Acnegen Chemical Contents : Isotretinoin
Acnegen Indication : Severe forms of nodulo-cystic acne resistant to therapy,cystic acne & acne conglobata, especially when the lesions involve the trunk

2011

Ostenil Plus (MD)

Career

Since its establishment, Bio-Gen has embraced HR policies that prioritize the personal development of its employees.

Within the framework of our corporate values, we encourage our employees to utilize their skills to the fullest and continuously support result-oriented working skills.

Business Development

Bio-Gen İlaç has carried out long-term studies through mergers with various businesses in the international market; It aims to increase the existing volumes of its business units and improve them by adding new customers.

Business Development Department:

Phone: +90 (312) 215 92 65-66

Fax: +90 (212) 215 92 64

Email: info@bio-gen.net

Acnegen 10 mg

Acnegen 20 mg

Isotretinoin Pharmaceutical form, Capsules, Soft Indications Severe forms of acne (such as nodular or conglobate acne or acne at risk of permanent scarring) resistant to adequate courses of standard therapy with systemic antibacterials and topical therapy.

Product category Dermatology

copyright

Ostenil Plus 40 mg/2 ml

OSTENIL^® Plus is a solution containing 40 mg / 2 ml hyaluronic acid for injection into the joint cavity.
Mannitol-stabilised high dose HA for sustained effect

OSTENIL^® PLUS is a unique combination of natural high dose HA (2%) + mannitol.
The formulation offers the possibility of reducing the number of intra-articular injections and increasing the intervals between injections.
OSTENIL^® PLUS reduces pain and improves function in osteoarthritis with very good tolerability.

Product category

Orthopedics

Artilane Pro Hydrolyzed Collagen

Artilane Pro is a Food Supplement containing Hydrolyzed Bovine Collagen, Hyaluronic acid, Lycopene, Quercetin, Vitamin C, Magnesium, Zinc and Coenzyme Q10. It is in disposable drinkable ampoule form. It does not contain sugar.

Artrodar 50 mg/30 capsules

Oral inhibition of interleukin-1 in the treatment of osteoarthritis.

DIACEREIN is indicated for the specific, long-term oral treatment of degenerative joint diseases (osteoarthritis and related diseases). DIACEREIN has a unique mode of action through inhibition of the production and activity of interleukin-1, the key mediator in the progression of osteoarthritis.

DIACEREIN is effective in reducing pain and functional impairment, the major symptoms of OA, and has shown structure-modifying effects with good gastrointestinal tolerability.

Product category

Orthopedics

Brunac Sterile Eye Drops 5%

Brunac Eye Drop contains N-Acetyl Cysteine. The molecule is a corneal collagenase enzyme inhibitor. It is indicated for corneal ulcers, keratitis of different etiologies, and corneal diseases arising from lacrimal secretion changes.

Ferosom Capsule

Ferosom Capsule is a food supplement containing Microencapsulated LCE Liposomal® Iron and vitamin C.

One pack contains 40 Capsules. Country of Origin is Canada. Ferosom does not contain gluten.

It is recommended for individuals aged 11 years and above to consume 1 capsule per day on an empty or full stomach.

Ferosom Stick

Ferosom Sticks is a food supplement containing Microencapsulated LCE Liposomal® Iron, Folic acid, Vitamin D, Vitamin B6, Vitamin B12 and Vitamin C. It is in disposable stick from that dissolves in the mouth.

One pack contains 20 Sticks. Country of Origin is Canada. Ferosom does not contain gluten.

It is recommended for individuals aged 11 and over to consume 1 stick per day on an empty or full stomach.

UVADEX®

Sterile Solution contains methoxsalen and is indicated for extracorporeal administration with Therakos CELLEX® Photopheresis System in the palliative treatment of the skin manifestations of Cutaneous T-Cell Lymphoma (CTCL) that is unresponsive to other forms of treatment.

Brumeton Eye Drops

Brumeton Eye Drop contains Betamethasone and Sodium sulfacetamide. It is indicated for the topical treatment and prophylaxis of non-purulent chronic and acute allergic blepharitis and blepharo conjunctivitis (seborral, allergic, staphylococcal).

Neuregen 30

Tablets containing UMP (Uridine 5-monophosphate), Apple extract with Polyphenols and Quinones, Magnesium, L-Methylfolate, Vitamin B12. It is Sugar free and gluten free.

Artilane 900 ml

Food supplement based on enzymatically hydrolyzed collagen of high purity, hyaluronic acid, lycopene, quercetin, and vitamin C for proper joint nutrition and help to reduce pain and inflammation associated with joint wear.

Ostenil 20 mg/2 ml

OSTENIL^® is a solution containing 20 mg / 2 ml hyaluronic acid for injection into the joint cavity. It is indicated for the treatment of symptoms of osteoarthritis. It has been shown to reduce pain and stiffness in the affected joint and to improve joint function which may last for several months.

Cetilar Cream 50ml

Cetilar Cream is a medical device used to relieve joint and musculoskeletal system pain quickly and reliably. It has a patented formula containing 7.5% cetylated fatty acids. Cetilar is designed for joints, muscles and tendons.

Therakos Cellex Photopheresis System

Designed for Excellence in ECP
The THERAKOS™ CELLEX™ Photopheresis System is the world’s only fully integrated and validated ECP system1.

What is the Rosacea Disease ?

Rosacea, also known as acne rosacea or by various other names, is a skin condition that primarily affects the central part of the face, including the nose, chin, forehead, and cheeks. It starts with episodes of flushing and burning and can progress to persistent redness, an increase in visible capillaries, swelling, and tissue overgrowth.

Triggers for facial flushing include sun exposure, emotional stress, sudden temperature changes (like washing with hot or cold water), cold winds, intense exercise, and alcohol consumption. Certain medications or cosmetics can also provoke flushing, as well as spicy foods and hot beverages such as coffee and tea.

How Does Rosacea Progress?

Rosacea is a slowly progressing condition and typically occurs in phases (flare-ups). There are four clinical stages:

Stage 1: Repeated episodes of burning and flushing in the face.
Stage 2: Persistent redness in the central part of the face and the formation of small visible blood vessels on the nose and cheeks.
Stage 3: The redness becomes darker and more persistent, and small red bumps or pimples (unlike blackheads or whiteheads) appear on the nose, cheeks, forehead, and chin.
Stage 4: Burning or continuous sensitivity in the eyes (ocular rosacea) and a red, swollen nose (rhinophyma).

ARTILANE PRO HYDROLISED COLLAGEN

Instructions: Shake the product before use.

What is Collagen? Collagen is a vital protein naturally found in cartilage, bones, and skin.

Collagen in Joints Collagen is essential for the normal functioning of joints. Large amounts of collagen are found in joint cartilage and bones. When collagen synthesis decreases in our bodies over time, cartilage wear can accelerate.

Collagen in Skin The presence of collagen in connective tissue is essential for a youthful and firm skin appearance. Taking collagen supplements orally helps maintain this appearance.

What is Hydrolyzed Collagen? Hydrolyzed Collagen is an easily absorbed form obtained by enzymatic hydrolysis of collagen into peptides. Also known as collagen peptides, collagen itself is a large molecule, and its size needs to be reduced to reach tissues and achieve the desired effects. Through hydrolysis, the molecules reach the desired size.

What is Our Source of Collagen? Our products only contain halal-certified bovine collagen.

Which Type of Collagen Should I Use? The important thing is that the collagen is hydrolyzed to be easily absorbable. Hydrolyzed collagen (in peptide form) is converted by relevant cells in our body into the necessary types (Type 1, 2, 3, etc.) wherever there is a need for collagen. Regardless of the type of collagen we get through food, our producing cells generate the required type of collagen.

What is Hyaluronic Acid?

Hyaluronic Acid in Joints It is the main component of the fluid between joints. Thanks to this molecule, the spaces between the joints remain lubricated, allowing easy movement. Joint cartilages are well-nourished and can maintain their health for many years without wearing out.

Hyaluronic Acid in Skin It is a moisture-retaining, volume-giving component that is abundant in the skin at a young age but decreases with age. It keeps the skin moist and youthful-looking.

Magnesium A mineral that helps reduce fatigue. It plays a role in normal energy metabolism. Additionally, it helps maintain bone and muscle functions.

Zinc A mineral involved in normal protein synthesis in our bodies. Along with vitamin C, it protects cells against oxidative damage.

Vitamin C A vitamin that contributes to the formation of collagen necessary for cartilage, bone, and skin health and is a powerful antioxidant.

Coenzyme Q10 This valuable coenzyme is important for skin beauty and helps prevent many ailments. It helps keep the skin youthful and is known for its fatigue-reducing effect. This feature also makes it valuable for joint mobility.

Lycopene Lycopene: Lycopene is a natural pigment responsible for the characteristic deep red color of ripe tomatoes and tomato products. It is a very effective antioxidant. It reacts with free radicals. When consumed through food, it is considered a nutrient that helps prevent tissue wear, maintain skin beauty, and support joint health.

Quercetin Quercetin is a pigment commonly found in the peels of many plants. As a powerful antioxidant, its consumption through food helps prevent cell damage and aging.

What is Collagen?

Collagen is a structural protein found in many organs in the body, primarily in the skin, bones, tendons, and ligaments. It is the most abundant protein in the body, constituting one-third of all body proteins. An essential component of connective tissue, collagen holds tissues together like glue. Abundantly present in the body, collagen serves various functions in different tissues and is the fundamental material that maintains body structure.

Types of Collagen:

The body contains many different types of collagen molecules. While their primary function is to support the structure of connective tissue, each type has specialized roles. The main types of collagen are:

Type 1 Collagen: Accounts for 90% of the body's collagen. It is found in tightly bundled fiber structures and is essential for forming bones, skin, tendons, fibrous cartilage, and teeth.
Type 2 Collagen: Found in elastic cartilage in joints, with collagen fibers more loosely packed than Type 1.
Type 3 Collagen: Fundamental in muscles, organs, and blood vessel structures.
Type 4 Collagen: Present in the layers of the skin.

As age progresses, collagen production in the body decreases, and the quality of collagen produced declines. This leads to loss of skin elasticity and the formation of wrinkles. Cartilage tissue also weakens, which can result in joint problems.

Foods That Increase Collagen Production:

Producing sufficient and high-quality collagen is crucial for health. Vitamin C plays a role in collagen production, making adequate intake essential. Copper mineral helps regulate the collagen produced, as it is involved in forming bonds that give collagen necessary strength. Therefore, adequate copper intake is also important.

Factors That Damage Collagen:

With age, collagen production in the body naturally decreases. Besides aging, certain conditions can damage existing collagen in the body. Damaged collagen production or structure can lead to various health issues. Excessive consumption of sugar and refined carbohydrates can inhibit collagen's ability to renew itself. Avoiding excessive sugar intake can help maintain the quality of collagen in the body. Prolonged exposure to sunlight can reduce collagen production. Thus, it's advisable to be cautious about excessive sun exposure to ensure adequate collagen synthesis. Smoking decreases collagen synthesis, delays wound healing, and can lead to wrinkles. Smoking also causes many serious diseases, so quitting smoking is crucial to prevent all these issues.

Benefits of Collagen Supplements:

Collagen is a widely present protein in the body, with many specialized subtypes. Those who use collagen supplements aim to increase their body's collagen levels for a healthier life. Collagen supplements can help prevent a wide range of undesired conditions, from hair health to cartilage, facial wrinkles, and heart diseases.

Collagen is abundantly found in the skin. With aging, collagen loss occurs in the inner layers of the skin, leading to loss of elasticity and increased vulnerability to damage. Wrinkles start to form as the skin loses its elasticity, gradually leading to an older appearance. Collagen supplements increase skin elasticity, improve moisture balance, and boost collagen density in the deeper layers of the skin. All these effects help prevent wrinkles and keep the skin looking youthful. Supplements provide anti-aging effects and are especially popular for facial use. Collagen serums can be applied directly to the facial area to promote healthy and youthful skin appearance.

Revolutionary Discovery: Cetylated Fatty Acids (CFA)

Cetylated fatty acids, a unique blend of plant-based fatty acids and cetyl alcohol, quickly absorb through the skin barrier to lubricate joints and muscles, soften tissues, and increase flexibility. How, you ask? Their cetylated structure stabilizes cell membranes and restores the function of damaged membranes, aiding in the recovery of joints and the musculoskeletal system. CFAs are patented components known for their high transcutaneous penetration power and they do not exhibit side effects. The use of these innovative cetylated fatty acids in topical applications could be revolutionary in the fields of health and sports due to their multifaceted advantages.

By stabilizing the cell membrane and restoring the function of damaged membranes, cetylated fatty acids are an ideal solution for joint and musculoskeletal system disorders. CFAs, known for their high transcutaneous penetration power, quickly absorb through the skin, directly reaching problematic areas and providing effective results. The absence of side effects is a major advantage for users, making these compounds a safe and effective option. Additionally, CFAs are notable for providing fast, effective, and high-quality treatment in sports injuries. These cetylated fatty acids have attracted the interest of sports physicians and are a unique and innovative ingredient proven to be suitable for athlete use, as they do not contain doping substances. Besides sports injuries, this product can also be used in significant joint disorders such as osteoarthritis, standing out with its quick, safe, and effective treatment.

The properties of softening tissues, increasing flexibility, and lubricating joints contribute to alleviating physical discomforts. Thus, cetylated fatty acids are an important supportive product for maintaining a healthy life.

Benefits of Liposomal Iron

Liposomal iron offers several advantages over standard iron supplements, including ease of use, better protection from observable side effects, and more effective utilization within the body due to higher absorption rates. It is absorbed more quickly and effectively without causing stomach discomfort. This makes it a more comfortable, safe, and ideal solution, especially for those with iron deficiency anemia. Liposomal iron increases the oxygen-carrying capacity of red blood cells by raising or maintaining iron levels, helping to alleviate symptoms of anemia such as fatigue, weakness, dizziness, headaches, concentration difficulties, brittle nails, hair loss, and other anemia-related symptoms.

The benefits of liposomal iron extend beyond health to the realms of beauty and skincare. A healthy body and proper oxygen distribution throughout the body ensure healthy organs, systems, and skin that is properly nourished from within through blood circulation, ultimately enhancing your quality of life. Proper oxygen distribution improves energy levels, making your day better. So, how does liposomal iron achieve this? The cells in our bodies are surrounded by a double phospholipid layer. Through liposome technology, iron is encapsulated in a dual phospholipid layer, mimicking the cell. This allows for maximum delivery to target tissues and cells. Liposomal iron provides higher absorption and bioavailability while also protecting against gastrointestinal side effects. Additionally, it maximizes benefits by protecting iron from enzymes and interactions with food in the body.

Among the various types of liposomal iron, some products stand out with additional advantages. For instance, liposomal iron products with an extra lair of protection such as LCE stands out due to its protective coating, minimizing the amount of liposomal iron digested in the digestive system and ensuring a higher percentage of intact liposomal iron is absorbed by the body. This results in a noticeable increase in the effectiveness of iron usage within the body compared to other liposomal iron products. Liposomal iron products with LCE protection are a standout dietary supplement for improving conditions such as anemia, supporting the circulatory system, enhancing general life standards, beauty, organ health, and daily energy levels.

What is Peripheral Neuropathic Pain?

Peripheral neuropathic pain arises from damage to the peripheral nerves, which are located outside the brain and spinal cord. This type of pain typically begins in the feet and hands and can spread throughout the body. Peripheral neuropathic pain stems from damaged nerve signals and manifests through various symptoms such as pain, burning, tingling, numbness, and a feeling of cold. Peripheral nerves in our nervous system can be damaged due to infections, metabolic disorders, trauma, toxins, hereditary conditions, or genetic factors, leading to numbness, burning, pain, and weakness, primarily in the hands and feet.

One of the common causes of peripheral neuropathic pain is diabetes. In individuals with diabetes, high blood sugar levels can damage nerves, resulting in peripheral neuropathic pain.

In the treatment of peripheral neuropathic pain, controlling the underlying disease can alleviate neuropathic pain symptoms. However, the most crucial approach is to reduce, stop, or eliminate peripheral-neuropathic pain by halting inflammation in the nerve or supporting the tissue damaged in specific areas of the nerve with supplements. Painkillers and physical therapy methods can also manage neuropathic pain. Nevertheless, we can say that some dietary supplements play a very prominent and clear role in peripheral neuropathic pain during the treatment process. Thanks to the unique contents offered to the body as dietary supplements, peripheral neuropathic pain involves not only pain management but also products that play an active role in providing a radical solution to patients' discomfort and that nourish and support the body with the right content at the correct levels to overcome this pain. With their quality, patient-friendly use, and positive feedback on effectiveness, these products have proven to be unique and innovative in public health.

What is Osteoarthrit?

Osteoarthritis, commonly referred to as "joint wear and tear," is a chronic condition that occurs due to the gradual deterioration of the cartilage tissue in the joints, leading to wear and tear, and a decrease in the fluid between the joints. This deterioration causes pain, stiffness, and movement limitations in the joints. It particularly affects joints such as the knees, hips, elbows, wrists, ankles, and spine.

Osteoarthritis, which can be caused by obesity, age, gender, various joint injuries, and genetic factors, negatively impacts the quality of life by making daily activities more difficult for individuals. In addition to pain and stiffness in the joints and limited movement, it also presents symptoms such as swelling in the joints, changes in the shape of the joints, stiffness, tenderness, and sounds coming from the joint. Osteoarthritis symptoms usually develop slowly and can worsen over time. These symptoms can affect the quality of life and make daily activities difficult.

Osteoarthritis is classified into 4 stages, and usually stages 2 and above are considered definite osteoarthritis. At lower stages, the joint space may not be significantly affected, and the damage may be minimal, while in high-stage osteoarthritis cases, there is a significant reduction in joint function. This reduction in joint function and the functional impairment it causes in the patient, along with pain, swelling, tenderness, and difficulty in movement, significantly affects the patient's quality of life. In osteoarthritis, in addition to the damage to the joint tissue, the reduction and damage of the internal content of the joint and the resulting internal and external damage, disintegration, and dysfunction of the joint is a condition that many people face due to various factors. So how is it treated?

The goal in the treatment of osteoarthritis is to reduce pain and improve joint function. Physical therapy applications, weight loss, certain oral medications, topical creams, and intra-articular injections can be used in treatment. Additionally, appropriate nutrition and weight control are important to slow down the progression of the disease. In the early stages of the disease, lifestyle and living standard changes may be sufficient or delay the progression of the disease; however, in advanced cases, external interventions are needed.

Wound Treatment with Collagen

Collagen is the most abundant protein in tissues and has various functions. One of these functions is its effectiveness in wound treatment. By acting as a scaffold for the growth of new cells and tissues, collagen supports wound healing. When a wound occurs, collagen, being a fibrous protein, enhances tissue integrity with its fibers, stops bleeding, provides moisture to the cells, and forms a matrix structure for the formation of new tissue and blood vessels. Collagen, by adhering to fibronectin, increases cell adhesion and helps in the formation and deposition of fibers, thereby enhancing tissue integrity and creating a suitable environment for wound healing. In wounds, collagen supports the healing process by acting as a scaffold for the growth of new cells and tissues. Additionally, the moisture-providing and infection-risk-reducing properties of collagen accelerate wound healing.

Collagen-based wound treatment products can be used in both chronic and acute wounds, such as surgical incisions, bedsores, and diabetic ulcers. These products play an effective role in strengthening the wound barrier and can be used effectively in the healing of especially chronic and non-healing wounds. When applied to wounds, these products strengthen the wound barrier and accelerate the healing process due to their collagen structure.

In conclusion, wound treatment with collagen is an important tool in modern wound care. This method helps wounds to heal more quickly and effectively, thereby improving the quality of life. Depending on the size and extent of the wounds on the body, collagen pad treatment can meet the body's need for the effects of collagen in wound repair, especially in wounds where there is a deficiency in the collagen layer or where most of the collagen layer has been lost due to the wound.

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